Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human IgG Fc
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity Predicted to be involved in several processes including activation of immune response defense response to other organism and phagocytosis Predicted to act upstream of or within several processes including immunoglobulin mediated immune response positive regulation of hypersensitivity and positive regulation of phagocytosis Located in extracellular space
ABclonal Technology 594 Rabbit anti-Human CD98
This gene is a member of the solute carrier family and encodes a cell surface transmembrane protein The protein exists as the heavy chain of a heterodimer covalently bound through di-sulfide bonds to one of several possible light chains The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids Alternatively spliced transcript variants encoding different isoforms have been characterized
ABclonal Technology 594 Rabbit anti-Human IL8
The protein encoded by this gene is interleukin-8 (IL-8) a major mediator of inflammation and a member of the CXC chemokine family IL-8 is secreted by macrophages neutrophils eosinophils T lymphocytes epithelial cells and fibroblasts guiding neutrophils to infection sites It is rapidly induced by bacterial and viral products and contributes to the proinflammatory cascade playing a role in systemic inflammatory response syndrome (SIRS) IL-8 is involved in conditions like bronchiolitis cystic fibrosis coronary artery disease and endothelial dysfunction It also promotes tumor migration invasion angiogenesis and metastasis IL-8 binds to its receptor (CXCR2) increasing blood vessel permeability Elevated IL-8 levels correlate with worsened disease outcomes including sepsis This gene is part of a CXC chemokine cluster on chromosome 4q
ABclonal Technology 700 Rabbit anti-Human CD94
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation Several genes of the C-type lectin superfamily including members of the NKG2 family are expressed by NK cells and may be involved in the regulation of NK cell function KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus Several transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 647 Rabbit anti-Human CD5
This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes T lymphocytes and a subset of B lymphocytes The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation Alternative splicing results in multiple transcript variants encoding different isoforms
ABclonal Technology PE Rabbit anti-Human CD55 mAb
This gene encodes a glycoprotein involved in the regulation of the complement cascade Binding of the encoded protein to complement proteins accelerates their decay thereby disrupting the cascade and preventing damage to host cells Antigens present on this protein constitute the Cromer blood group system (CROM) Alternative splicing results in multiple transcript variants The predominant transcript variant encodes a membrane-bound protein but alternatively spliced transcripts may produce soluble proteins
ABclonal Technology 450 Rabbit anti-Human CD97
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors which mediate cell-cell interactions These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit which associate at the cell surface as a receptor complex The encoded protein may play a role in cell adhesion as well as leukocyte recruitment activation and migration and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55 Expression of this gene may play a role in the progression of several types of cancer Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19
ABclonal Technology PE Rabbit anti-Human CD44V6
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions cell adhesion and migration It is a receptor for hyaluronic acid (HA) and can also interact with other ligands such as osteopontin collagens and matrix metalloproteinases (MMPs) This protein participates in a wide variety of cellular functions including lymphocyte activation recirculation and homing hematopoiesis and tumor metastasis Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms however the full length nature of some of these variants has not been determined Alternative splicing is the basis for the structural and functional diversity of this protein and may be related to tumor metastasis
Medchemexpress LLC FITC-conjugated Rabbit Anti-Human IgG H&L | 50 UL
FITC-conjugated Rabbit Anti-Human IgG H&L is a fluorescein isothiocyanate (FITC) labeled and rabbit-derived polyclonal antibody, which served as the secondary antibody.
- Host: Rabbit
- Immunogen: Native Human IgG
- Conjugation: FITC
- Modification: Unmodified
- Isotype: IgG
- Appearance: Liquid
- Applications: ICC/IF, FC
- Clonality: Polyclonal
- Species reactivity: Human
- Purity: Affinity purified
- Storage & stability: Stored at -20°C for 1 year. Protect from light. Avoid repeated freeze / thaw cycles.
Abcam Rabbit Anti-Human IgA H&L (Biotin).
Rabbit Anti-Human IgA H&L (Biotin).
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology 488 Rabbit anti-Human TNF-a
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily This cytokine is mainly secreted by macrophages It can bind to and thus functions through its receptors TNFRSF1A TNFR1 and TNFRSF1B TNFBR This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation differentiation apoptosis lipid metabolism and coagulation This cytokine has been implicated in a variety of diseases including autoimmune diseases insulin resistance psoriasis rheumatoid arthritis ankylosing spondylitis tuberculosis autosomal dominant polycystic kidney disease and cancer Mutations in this gene affect susceptibility to cerebral malaria septic shock and Alzheimer disease Knockout studies in mice also suggested the neuroprotective function of this cytokine
ABclonal Technology 488 Rabbit anti-Human CD68
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages It is a member of the lysosomal endosomal-associated membrane glycoprotein (LAMP) family The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins The protein is also a member of the scavenger receptor family Scavenger receptors typically function to clear cellular debris promote phagocytosis and mediate the recruitment and activation of macrophages Alternative splicing results in multiple transcripts encoding different isoforms
ABclonal Technology PE Rabbit anti-Human CD146 mAb
Melanoma cell adhesion molecule (MCAM MUC18 CD146) is an immunoglobulin superfamily member that acts as a cell surface adhesion protein and a marker of melanoma progression and metastasis It is expressed in vascular endothelial cells activated T lymphocytes smooth muscle and bone marrow stromal cells MCAM expression increases in endothelial cells in angiogenesis-related disorders including inflammatory bowel disease Crohn s disease rheumatoid arthritis tumors and chronic renal failure In the hematopoietic microenvironment MCAM-expressing human mesenchymal stromal cells (hMSC) maintain hematopoietic stem and progenitor cell (HSPC) self-renewal MCAM also plays a role in multiple sclerosis facilitating lymphocyte transmigration across the blood-brain barrier leading to inflammatory lesions in the central nervous system
ABclonal Technology 488 Rabbit anti-Human CD74
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which when bound to the encoded protein initiates survival pathways and cell proliferation This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta) Multiple alternatively spliced transcript variants encoding different isoforms have been identified